Prediction of HLA genotypes from single-cell transcriptome data

Prediction of HLA genotypes from single-cell transcriptome data

The human leukocyte antigen (HLA) locus plays a central role in adaptive immune function and has significant clinical implications for tissue transplant compatibility and allelic disease associations. Studies using bulk-cell RNA sequencing have demonstrated that HLA transcription may be regulated in...

Full description

Bibliographic Details
Main Authors: Benjamin D. Solomon, Hong Zheng, Laura W. Dillon, Jason D. Goldman, Christopher S. Hourigan, James R. Heath, Purvesh Khatri
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Immunology
Subjects:
HLA typing algorithm
next-generation sequencing data (NGS)
HLA genotype
single-cell sequencing (scRNA-seq)
human leukocyte antigen (HLA)
major histocompatibility (MHC)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1146826/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1146826/full

Similar Items