Yes-Associated Protein (YAP) Facilitates Pressure Overload–Induced Dysfunction in the Diabetic Heart

Yes-Associated Protein (YAP) Facilitates Pressure Overload–Induced Dysfunction in the Diabetic Heart

Summary: Patients with diabetes are more prone to developing heart failure in the presence of high blood pressure than those without diabetes. Yes-associated protein (YAP), a key effector of the Hippo signaling pathway, is persistently activated in diabetic hearts, and YAP plays an essential role in...

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Bibliographic Details
Main Authors: Shohei Ikeda, MD, PhD, Risa Mukai, MD, PhD, Wataru Mizushima, MD, PhD, Peiyong Zhai, MD, PhD, Shin-ichi Oka, PhD, Michinari Nakamura, MD, PhD, Dominic P. Del Re, PhD, Sebastiano Sciarretta, MD, PhD, Chiao-Po Hsu, MD, PhD, Hiroaki Shimokawa, MD, PhD, Junichi Sadoshima, MD, PhD
Format: Article
Language:English
Published: Elsevier 2019-09-01
Series:JACC: Basic to Translational Science
Online Access:http://www.sciencedirect.com/science/article/pii/S2452302X1930141X

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http://www.sciencedirect.com/science/article/pii/S2452302X1930141X

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