Yes-Associated Protein (YAP) Facilitates Pressure Overload–Induced Dysfunction in the Diabetic Heart

Yes-Associated Protein (YAP) Facilitates Pressure Overload–Induced Dysfunction in the Diabetic Heart

Summary: Patients with diabetes are more prone to developing heart failure in the presence of high blood pressure than those without diabetes. Yes-associated protein (YAP), a key effector of the Hippo signaling pathway, is persistently activated in diabetic hearts, and YAP plays an essential role in...

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Bibliographic Details
Main Authors: Shohei Ikeda, MD, PhD, Risa Mukai, MD, PhD, Wataru Mizushima, MD, PhD, Peiyong Zhai, MD, PhD, Shin-ichi Oka, PhD, Michinari Nakamura, MD, PhD, Dominic P. Del Re, PhD, Sebastiano Sciarretta, MD, PhD, Chiao-Po Hsu, MD, PhD, Hiroaki Shimokawa, MD, PhD, Junichi Sadoshima, MD, PhD
Format: Article
Language:English
Published: Elsevier 2019-09-01
Series:JACC: Basic to Translational Science
Online Access:http://www.sciencedirect.com/science/article/pii/S2452302X1930141X
Description
Summary:Summary: Patients with diabetes are more prone to developing heart failure in the presence of high blood pressure than those without diabetes. Yes-associated protein (YAP), a key effector of the Hippo signaling pathway, is persistently activated in diabetic hearts, and YAP plays an essential role in mediating the exacerbation of heart failure in response to pressure overload in the hearts of mice fed a high-fat diet. YAP induced dedifferentiation of cardiomyocytes through activation of transcriptional enhancer factor 1 (TEAD1), a transcription factor. Thus, YAP and TEAD1 are promising therapeutic targets for diabetic patients with high blood pressure to prevent the development of heart failure. Key Words: diabetes, diabetic cardiomyopathy, Hippo pathway, pressure overload
ISSN:2452-302X

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