Rotundifuran Induces Ferroptotic Cell Death and Mitochondria Permeability Transition in Lung Cancer Cells

Rotundifuran Induces Ferroptotic Cell Death and Mitochondria Permeability Transition in Lung Cancer Cells

Rotundifuran (RF), a potent anti-inflammatory and anti-cancer compound, is a natural compound predominantly present in <i>Vitex Rotundifolia</i>. Herein, we investigated the effects of RF on the growth of lung cancer cells. Our findings suggested that RF inhibits cell growth, highlightin...

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Bibliographic Details
Main Authors: Myung-Ji Kang, Dong-Oh Moon, Ji-Yoon Park, Namho Kim, Su Hyeon Lee, Hyung Won Ryu, Yang Hoon Huh, Hyun-Sun Lee, Mun-Ock Kim
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Biomedicines
Subjects:
rotundifuran
ferroptosis
reactive oxygen species (ROS)
mitochondria permeability transition (MPT)
Online Access:https://www.mdpi.com/2227-9059/12/3/576

Internet

https://www.mdpi.com/2227-9059/12/3/576

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