PfHDAC1 is an essential regulator of P. falciparum asexual proliferation and host cell invasion genes with a dynamic genomic occupancy responsive to artemisinin stress

PfHDAC1 is an essential regulator of P. falciparum asexual proliferation and host cell invasion genes with a dynamic genomic occupancy responsive to artemisinin stress

ABSTRACT Plasmodium falciparum, the deadly protozoan parasite responsible for malaria, has a tightly regulated gene expression profile closely linked to its intraerythrocytic development cycle. Epigenetic modifiers of the histone acetylation code have been identified as key regulators of the parasit...

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Bibliographic Details
Main Authors: Abhishek Kanyal, Bhagyashree Deshmukh, Heledd Davies, D. V. Mamatharani, Dilsha Farheen, Moritz Treeck, Krishanpal Karmodiya
Format: Article
Language:English
Published: American Society for Microbiology 2024-06-01
Series:mBio
Subjects:
malaria
Plasmodium falciparum
histone deacetylase
PfHDAC1
transcriptomics
artemisinin resistance
Online Access:https://journals.asm.org/doi/10.1128/mbio.02377-23

Internet

https://journals.asm.org/doi/10.1128/mbio.02377-23

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