Ligustrazin increases lung cell autophagy and ameliorates paraquat-induced pulmonary fibrosis by inhibiting PI3K/Akt/mTOR and hedgehog signalling via increasing miR-193a expression

Ligustrazin increases lung cell autophagy and ameliorates paraquat-induced pulmonary fibrosis by inhibiting PI3K/Akt/mTOR and hedgehog signalling via increasing miR-193a expression

Abstract Background Reactive oxygen species (ROS) levels largely determine pulmonary fibrosis. Antioxidants have been found to ameliorate lung fibrosis after long-term paraquat (PQ) exposure. The effects of antioxidants, however, on the signalling pathways involved in PQ-induced lung fibrosis have n...

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Bibliographic Details
Main Authors: Ming-wei Liu, Mei-xian Su, Deng-yun Tang, Li Hao, Xiang-Han Xun, Yun-qiao Huang
Format: Article
Language:English
Published: BMC 2019-02-01
Series:BMC Pulmonary Medicine
Subjects:
Lung fibrosis
Ligustrazin
Paraquat
miR-193a
Akt
mTOR
Online Access:http://link.springer.com/article/10.1186/s12890-019-0799-5

Internet

http://link.springer.com/article/10.1186/s12890-019-0799-5

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