Evidence for Dysfunction of the Nigrostriatal Pathway in the R6/1 Line of Transgenic Huntington's Disease Mice

Evidence for Dysfunction of the Nigrostriatal Pathway in the R6/1 Line of Transgenic Huntington's Disease Mice

The present multidisciplinary study examined nigrostriatal dopamine and striatal amino acid transmission in the R6/1 line of transgenic Huntington's disease (HD) mice expressing exon 1 of the HD gene with 115 CAG repeats. Although the number of tyrosine hydroxylase-positive neurons was not redu...

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Bibliographic Details
Main Authors: Å. Petersén, Z. Puschban, J. Lotharius, B. NicNiocaill, P. Wiekop, W.T. O'Connor, P. Brundin
Format: Article
Language:English
Published: Elsevier 2002-10-01
Series:Neurobiology of Disease
Subjects:
dopamine
Huntington's disease
malonate
microdialysis
striatum
substantia nigra
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996102905346

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http://www.sciencedirect.com/science/article/pii/S0969996102905346

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