Histone lactylation couples cellular metabolism with developmental gene regulatory networks

Abstract Embryonic cells exhibit diverse metabolic states. Recent studies have demonstrated that metabolic reprogramming drives changes in cell identity by affecting gene expression. However, the connection between cellular metabolism and gene expression remains poorly understood. Here we report tha...

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Bibliographic Details
Main Authors: Fjodor Merkuri, Megan Rothstein, Marcos Simoes-Costa
Format: Article
Language:English
Published: Nature Portfolio 2024-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-44121-1