Crystal structure of binase does not reflect its native conformation

Crystal structure of binase does not reflect its native conformation

Cytotoxic ribonucleases (RNases) of the T1 family, including binase, the secreted guanyl-preferring RNase of Bacillus pumilus, are considered as promising agents of alternative anticancer chemotherapy. Binase has a selective apoptosis-inducing action against cells expressing oncogenes ras, kit, AML-...

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Bibliographic Details
Main Authors: E.V. Dudkina, V.V. Ulyanova, Yu.V. Surchenko, N.T. Nguen, A.I. Kolpakov, O.N. Ilinskaya
Format: Article
Language:English
Published: Kazan Federal University 2018-12-01
Series:Učënye Zapiski Kazanskogo Universiteta. Seriâ Estestvennye Nauki
Subjects:
ribonuclease
binase
glu43ala/phe81ala mutant
crystal structure
native conformation
cytotoxity
Online Access:https://kpfu.ru/crystal-structure-of-binase-does-not-reflect-its_382296.html

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