Molecular determinants of ASIC1 modulation by divalent cations

Abstract Acid-sensing ion channels (ASICs) are proton-gated cation channels widely expressed in the nervous system. ASIC gating is modulated by divalent cations as well as small molecules; however, the molecular determinants of gating modulation by divalent cations are not well understood. Previousl...

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Bibliographic Details
Main Authors: Yi Liu, Jichun Ma, Renee L. DesJarlais, Rebecca Hagan, Jason Rech, Changlu Liu, Robyn Miller, Jeffrey Schoellerman, Jinquan Luo, Michael Letavic, Bruce Grasberger, Michael P. Maher
Format: Article
Language:English
Published: Nature Portfolio 2024-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-024-52845-3