QSAR Studies, Synthesis, and Biological Evaluation of New Pyrimido-Isoquinolin-Quinone Derivatives against Methicillin-Resistant <i>Staphylococcus aureus</i>

QSAR Studies, Synthesis, and Biological Evaluation of New Pyrimido-Isoquinolin-Quinone Derivatives against Methicillin-Resistant <i>Staphylococcus aureus</i>

According to the WHO, antimicrobial resistance is among the top 10 threats to global health. Due to increased resistance rates, an increase in the mortality and morbidity of patients has been observed, with projections of more than 10 million deaths associated with infections caused by antibacterial...

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Bibliographic Details
Main Authors: Juan Andrades-Lagos, Javier Campanini-Salinas, Gianfranco Sabadini, Victor Andrade, Jaime Mella, David Vásquez-Velásquez
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Pharmaceuticals
Subjects:
antibacterial agents
drug discovery
quinone antibiotics
structure-activity relationships
3D-QSAR
CoMFA
Online Access:https://www.mdpi.com/1424-8247/16/11/1621

Internet

https://www.mdpi.com/1424-8247/16/11/1621

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