The antibody-binding Fc gamma receptor IIIa / CD16a is N-glycosylated with high occupancy at all five sites

The antibody-binding Fc gamma receptor IIIa / CD16a is N-glycosylated with high occupancy at all five sites

The antibody-binding Fc γ receptors (FcγRs) trigger life-saving immune responses and many therapeutic monoclonal antibodies require FcγR engagement for full effect. One proven strategy to improve the efficacy of antibody therapies is to increase receptor binding affinity, in particular binding to Fc...

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Bibliographic Details
Main Authors: Elizabeth A. Lampros, Paul G. Kremer, Jesús S. Aguilar Díaz de León, Elijah T. Roberts, Maria Carolina Rodriguez Benavente, I. Jonathan Amster, Adam W. Barb
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Current Research in Immunology
Subjects:
Glycobiology
PNGase-F
Antibody-binding receptor
Mass spectrometry
Online Access:http://www.sciencedirect.com/science/article/pii/S2590255522000105

Internet

http://www.sciencedirect.com/science/article/pii/S2590255522000105

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