The antibody-binding Fc gamma receptor IIIa / CD16a is N-glycosylated with high occupancy at all five sites
The antibody-binding Fc γ receptors (FcγRs) trigger life-saving immune responses and many therapeutic monoclonal antibodies require FcγR engagement for full effect. One proven strategy to improve the efficacy of antibody therapies is to increase receptor binding affinity, in particular binding to Fc...
Main Authors: | Elizabeth A. Lampros, Paul G. Kremer, Jesús S. Aguilar Díaz de León, Elijah T. Roberts, Maria Carolina Rodriguez Benavente, I. Jonathan Amster, Adam W. Barb |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2022-01-01
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Series: | Current Research in Immunology |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2590255522000105 |
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