FTY720 Inhibits Expansion of Breast Cancer Stem Cells via PP2A Activation

FTY720 Inhibits Expansion of Breast Cancer Stem Cells via PP2A Activation

Growing evidence suggests that breast cancer originates from a minor population of cancer cells termed cancer stem cells (CSCs), which can be identified by aldehyde dehydrogenase (ALDH) activity-based flow cytometry analysis. However, novel therapeutic drugs for the eradication of CSCs have not been...

Full description

Bibliographic Details
Main Authors: Naoya Hirata, Shigeru Yamada, Shota Yanagida, Atsushi Ono, Yasunari Kanda
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
ALDH
cancer stem cells
drug repositioning
SphK1
FTY720
PP2A
Online Access:https://www.mdpi.com/1422-0067/22/14/7259

Internet

https://www.mdpi.com/1422-0067/22/14/7259

Similar Items