Design and Synthesis of a Novel 4-aryl-N-(2-alkoxythieno [2,3-<i>b</i>]pyrazine-3-yl)-4-arylpiperazine-1-carboxamide DGG200064 Showed Therapeutic Effect on Colon Cancer through G2/M Arrest

Design and Synthesis of a Novel 4-aryl-N-(2-alkoxythieno [2,3-<i>b</i>]pyrazine-3-yl)-4-arylpiperazine-1-carboxamide DGG200064 Showed Therapeutic Effect on Colon Cancer through G2/M Arrest

Cancer cells are characterized by an abnormal cell cycle. Therefore, the cell cycle has been a potential target for cancer therapeutic agents. We developed a new lead compound, <b>DGG200064</b> (<b>7c</b>) with a 2-alkoxythieno [2,3-<i>b</i>]pyrazine-3-yl)-4-arylp...

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Bibliographic Details
Main Authors: Eun-Sil Lee, Nayeon Kim, Joon Hee Kang, Aizhan Abdildinova, Seon-Hyeong Lee, Myung Hwi Lee, Nam Sook Kang, Tae-Sung Koo, Soo-Youl Kim, Young-Dae Gong
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Pharmaceuticals
Subjects:
lead compound
cell cycle arrest
CDC4-cJUN
G2/M arrest
anticancer activity
colorectal cancer
Online Access:https://www.mdpi.com/1424-8247/15/5/502

Internet

https://www.mdpi.com/1424-8247/15/5/502

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