Differential Utilization and Localization of ErbB Receptor Tyrosine Kinases in Skin Compared to Normal and Malignant Keratinocytes

Differential Utilization and Localization of ErbB Receptor Tyrosine Kinases in Skin Compared to Normal and Malignant Keratinocytes

Induction of heparin-binding epidermal growth factorlike growth factor (HB-EGF) mRNA in mouse skin organ culture was blocked by two pan-ErbB receptor tyrosine kinase (RTK) inhibitors but not by genetic ablation of ErbB1, suggesting involvement of multiple ErbB species in skin physiology. Human skin,...

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Bibliographic Details
Main Authors: Stefan W. Stoll, Sanjay Kansra, Scott Peshick, David W. Fry, Wilbur R. Leopold, Jane F. Wiesen, Maria Sibilia, Tong Zhang, Zena Werb, Rik Derynck, Erwin F. Wagner, James T. Elder
Format: Article
Language:English
Published: Elsevier 2001-01-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
ErbB receptors
skin organ culture
keratinocytes
heparin-binding EGF-like growth factor
receptor tyrosine kinase
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558601800373

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http://www.sciencedirect.com/science/article/pii/S1476558601800373

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