Galectin-3 Released by Pancreatic Ductal Adenocarcinoma Suppresses γδ T Cell Proliferation but Not Their Cytotoxicity

Galectin-3 Released by Pancreatic Ductal Adenocarcinoma Suppresses γδ T Cell Proliferation but Not Their Cytotoxicity

Pancreatic ductal adenocarcinoma (PDAC) is characterized by an immunosuppressive tumor microenvironment with a dense desmoplastic stroma. The expression of β-galactoside-binding protein galectin-3 is regarded as an intrinsic tumor escape mechanism for inhibition of tumor-infiltrating T cell function...

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Bibliographic Details
Main Authors: Daniel Gonnermann, Hans-Heinrich Oberg, Marcus Lettau, Matthias Peipp, Dirk Bauerschlag, Susanne Sebens, Dieter Kabelitz, Daniela Wesch
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Immunology
Subjects:
T cells
gammadelta T cells
pancreatic cancer
galectin-3
α3β1 integrin
bispecific antibodies
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01328/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01328/full

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