Chronic cortisol differentially impacts stem cell-derived astrocytes from major depressive disorder patients

Chronic cortisol differentially impacts stem cell-derived astrocytes from major depressive disorder patients

Abstract Major depressive disorder (MDD) is a prevalent psychiatric disorder, and exposure to stress is a robust risk factor for MDD. Clinical data and rodent models have indicated the negative impact of chronic exposure to stress-induced hormones like cortisol on brain volume, memory, and cell meta...

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Bibliographic Details
Main Authors: Kelly J. Heard, Maxim N. Shokhirev, Caroline Becronis, Callie Fredlender, Nadia Zahid, Amy T. Le, Yuan Ji, Michelle Skime, Timothy Nelson, Daniel Hall-Flavin, Richard Weinshilboum, Fred H. Gage, Krishna C. Vadodaria
Format: Article
Language:English
Published: Nature Publishing Group 2021-11-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-021-01733-9

Internet

https://doi.org/10.1038/s41398-021-01733-9

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