The Janus-faced nature of complement in hemodialysis: interplay between complement, inflammation, and bioincompatibility unveiling a self-amplifying loop contributing to organ damage

The Janus-faced nature of complement in hemodialysis: interplay between complement, inflammation, and bioincompatibility unveiling a self-amplifying loop contributing to organ damage

In hemodialysis (HD), complement activation, bioincompatibility, and inflammation are intricately intertwined. In the 1970s, as HD became a routine therapy, the observation of complement pathway activation and transient leukopenia by cellulosic dialysis membranes triggered the bioincompatibility deb...

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Bibliographic Details
Main Authors: Bernard Canaud, Peter Stenvinkel, Rebecca Scheiwe, Sonja Steppan, Sudhir Bowry, Giuseppe Castellano
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Nephrology
Subjects:
inflammation
complement
biocompatibility
dialysis
technology
clinical impact
Online Access:https://www.frontiersin.org/articles/10.3389/fneph.2024.1455321/full

Internet

https://www.frontiersin.org/articles/10.3389/fneph.2024.1455321/full

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