Individual MHCI restricted T-cell receptors are characterized by a unique peptide recognition signature
Effective immunity requires that a limited TCR repertoire is able to recognize a vast number of foreign peptide-MHCI. This challenge is overcome by the ability of individual TCRs to recognize large numbers of peptides. Recently, it was demonstrated that MHCI-restricted TCRs can recognize up to 10^6...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2013-07-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00199/full |
| _version_ | 1818231403212439552 |
|---|---|
| author | Linda eWooldridge |
| author_facet | Linda eWooldridge |
| author_sort | Linda eWooldridge |
| collection | DOAJ |
| description | Effective immunity requires that a limited TCR repertoire is able to recognize a vast number of foreign peptide-MHCI. This challenge is overcome by the ability of individual TCRs to recognize large numbers of peptides. Recently, it was demonstrated that MHCI-restricted TCRs can recognize up to 10^6 peptides of a defined length. Astonishingly, this remarkable level of promiscuity does not extend to peptides of different lengths, a fundamental observation that has broad implications for CD8+ T-cell immunity. In particular, the findings suggest that effective immunity can only be achieved by mobilization of "length-matched" CD8+ T-cell clonotypes. Overall, recent findings suggest that every TCR is specific for a unique set of peptides, which can be described as a unique "peptide recognition signature" and consists of three components: 1) peptide length preference, 2) number of peptides recognized; and, 3) sequence identity (e.g. self versus pathogen derived). In future, the ability to deconvolute peptide recognition signatures across the normal and pathogenic repertoire will be essential for understanding the system requirements for effective CD8+ T-cell immunity and elucidating mechanisms which underlie CD8+ T-cell mediated disease. |
| first_indexed | 2024-12-12T10:49:50Z |
| format | Article |
| id | doaj.art-753f0b9334d54ffca00980a3c2e356f4 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-12T10:49:50Z |
| publishDate | 2013-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-753f0b9334d54ffca00980a3c2e356f42022-12-22T00:26:49ZengFrontiers Media S.A.Frontiers in Immunology1664-32242013-07-01410.3389/fimmu.2013.0019954202Individual MHCI restricted T-cell receptors are characterized by a unique peptide recognition signatureLinda eWooldridge0University of BristolEffective immunity requires that a limited TCR repertoire is able to recognize a vast number of foreign peptide-MHCI. This challenge is overcome by the ability of individual TCRs to recognize large numbers of peptides. Recently, it was demonstrated that MHCI-restricted TCRs can recognize up to 10^6 peptides of a defined length. Astonishingly, this remarkable level of promiscuity does not extend to peptides of different lengths, a fundamental observation that has broad implications for CD8+ T-cell immunity. In particular, the findings suggest that effective immunity can only be achieved by mobilization of "length-matched" CD8+ T-cell clonotypes. Overall, recent findings suggest that every TCR is specific for a unique set of peptides, which can be described as a unique "peptide recognition signature" and consists of three components: 1) peptide length preference, 2) number of peptides recognized; and, 3) sequence identity (e.g. self versus pathogen derived). In future, the ability to deconvolute peptide recognition signatures across the normal and pathogenic repertoire will be essential for understanding the system requirements for effective CD8+ T-cell immunity and elucidating mechanisms which underlie CD8+ T-cell mediated disease.http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00199/fullAutoimmunityVaccinationalloreactivityMHCI peptide lengthCD8 T-cell immunityT-cell cross-reactivity |
| spellingShingle | Linda eWooldridge Individual MHCI restricted T-cell receptors are characterized by a unique peptide recognition signature Frontiers in Immunology Autoimmunity Vaccination alloreactivity MHCI peptide length CD8 T-cell immunity T-cell cross-reactivity |
| title | Individual MHCI restricted T-cell receptors are characterized by a unique peptide recognition signature |
| title_full | Individual MHCI restricted T-cell receptors are characterized by a unique peptide recognition signature |
| title_fullStr | Individual MHCI restricted T-cell receptors are characterized by a unique peptide recognition signature |
| title_full_unstemmed | Individual MHCI restricted T-cell receptors are characterized by a unique peptide recognition signature |
| title_short | Individual MHCI restricted T-cell receptors are characterized by a unique peptide recognition signature |
| title_sort | individual mhci restricted t cell receptors are characterized by a unique peptide recognition signature |
| topic | Autoimmunity Vaccination alloreactivity MHCI peptide length CD8 T-cell immunity T-cell cross-reactivity |
| url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00199/full |
| work_keys_str_mv | AT lindaewooldridge individualmhcirestrictedtcellreceptorsarecharacterizedbyauniquepeptiderecognitionsignature |