Pericyte remodeling is deficient in the aged brain and contributes to impaired capillary flow and structure

Using in vivo two-photon imaging, Berthiaume et al. demonstrate how pericyte loss during aging could contribute to deterioration of cerebral blood flow. They also show how pericyte remodeling reduces the deleterious effects of pericyte loss.

Bibliographic Details
Main Authors: Andrée-Anne Berthiaume, Franca Schmid, Stefan Stamenkovic, Vanessa Coelho-Santos, Cara D. Nielson, Bruno Weber, Mark W. Majesky, Andy Y. Shih
Format: Article
Language:English
Published: Nature Portfolio 2022-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-33464-w