Quinic acid alleviates high-fat diet-induced neuroinflammation by inhibiting DR3/IKK/NF-κB signaling via gut microbial tryptophan metabolites

Quinic acid alleviates high-fat diet-induced neuroinflammation by inhibiting DR3/IKK/NF-κB signaling via gut microbial tryptophan metabolites

With the increasing of aging population and the consumption of high-fat diets (HFD), the incidence of Alzheimer’s disease (AD) has skyrocketed. Natural antioxidants show promising potential in the prevention of AD, as oxidative stress and neuroinflammation are two hallmarks of AD pathogenesis. Here,...

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Bibliographic Details
Main Authors: Sen Li, Yuwei Cai, Tong Guan, Yu Zhang, Kai Huang, Ze Zhang, Wangqing Cao, Xiao Guan
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Gut Microbes
Subjects:
High-fat diet
Alzheimer’s disease
Neuroinflammation
Oxidative stress
Quinic acid
Tryptophan metabolism
Online Access:https://www.tandfonline.com/doi/10.1080/19490976.2024.2374608

Internet

https://www.tandfonline.com/doi/10.1080/19490976.2024.2374608

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