Flavivirus Nonstructural Protein NS5 Dysregulates HSP90 to Broadly Inhibit JAK/STAT Signaling

Flavivirus Nonstructural Protein NS5 Dysregulates HSP90 to Broadly Inhibit JAK/STAT Signaling

Pathogenic flaviviruses antagonize host cell Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling downstream of interferons α/β. Here, we show that flaviviruses inhibit JAK/STAT signaling induced by a wide range of cytokines beyond interferon, including interleukins. Th...

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Bibliographic Details
Main Authors: Justin A. Roby, Katharina Esser-Nobis, Elyse C. Dewey-Verstelle, Marian R. Fairgrieve, Johannes Schwerk, Amy Y. Lu, Frank W. Soveg, Emily A. Hemann, Lauren D. Hatfield, Brian C. Keller, Alexander Shapiro, Adriana Forero, Jennifer E. Stencel-Baerenwald, Ram Savan, Michael Gale
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cells
Subjects:
flavivirus
JAK/STAT
cytokine
West Nile virus
<i>Zika virus</i>
HSP90
Online Access:https://www.mdpi.com/2073-4409/9/4/899

Internet

https://www.mdpi.com/2073-4409/9/4/899

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