Tbx6 controls left-right asymmetry through regulation of Gdf1

The Tbx6 transcription factor plays multiple roles during gastrulation, somite formation and body axis determination. One of the notable features of the Tbx6 homozygous mutant phenotype is randomization of left/right axis determination. Cilia of the node are morphologically abnormal, leading to the...

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Bibliographic Details
Main Authors: Daniel Concepcion, Hiroshi Hamada, Virginia E. Papaioannou
Format: Article
Language:English
Published: The Company of Biologists 2018-05-01
Series:Biology Open
Subjects:
Online Access:http://bio.biologists.org/content/7/5/bio032565