PITX2 enhances progression of lung adenocarcinoma by transcriptionally regulating WNT3A and activating Wnt/β-catenin signaling pathway

PITX2 enhances progression of lung adenocarcinoma by transcriptionally regulating WNT3A and activating Wnt/β-catenin signaling pathway

Abstract Background The homeodomain transcription factor, PITX2 is associated with tumorigenesis of multiple cancers. In this research, we aimed to study the expression, function and mechanism of PITX2 in lung adenocarcinoma (LUAD). Methods The TCGA dataset was used to analyze the expression and cli...

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Bibliographic Details
Main Authors: Jing Luo, Yu Yao, Saiguang Ji, Qi Sun, Yang Xu, Kaichao Liu, Qiang Diao, Yong Qiang, Yi Shen
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Cancer Cell International
Subjects:
PITX2
Lung adenocarcinoma
Wnt/β-catenin
miR-140-5p
Online Access:http://link.springer.com/article/10.1186/s12935-019-0800-7

Internet

http://link.springer.com/article/10.1186/s12935-019-0800-7

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