BORIS/CTCFL epigenetically reprograms clustered CTCF binding sites into alternative transcriptional start sites

BORIS/CTCFL epigenetically reprograms clustered CTCF binding sites into alternative transcriptional start sites

Abstract Background Pervasive usage of alternative promoters leads to the deregulation of gene expression in carcinogenesis and may drive the emergence of new genes in spermatogenesis. However, little is known regarding the mechanisms underpinning the activation of alternative promoters. Results Her...

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Bibliographic Details
Main Authors: Elena M. Pugacheva, Dharmendra Nath Bhatt, Samuel Rivero-Hinojosa, Md Tajmul, Liron Fedida, Emma Price, Yon Ji, Dmitri Loukinov, Alexander V. Strunnikov, Bing Ren, Victor V. Lobanenkov
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Genome Biology
Subjects:
CTCF
CTCFL/BORIS
Alternative transcription
Cancer
Germ cells
Online Access:https://doi.org/10.1186/s13059-024-03175-0

Internet

https://doi.org/10.1186/s13059-024-03175-0

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