BMAL1/p53 mediating bronchial epithelial cell autophagy contributes to PM2.5-aggravated asthma

BMAL1/p53 mediating bronchial epithelial cell autophagy contributes to PM2.5-aggravated asthma

Abstract Background Fine particulate matter (PM2.5) is associated with increased incidence and severity of asthma. PM2.5 exposure disrupts airway epithelial cells, which elicits and sustains PM2.5-induced airway inflammation and remodeling. However, the mechanisms underlying development and exacerba...

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Bibliographic Details
Main Authors: Shuai-Jun Chen, Yi Huang, Fan Yu, Xiao Feng, Yuan-Yi Zheng, Qian Li, Qian Niu, Ye-Han Jiang, Li-Qin Zhao, Meng Wang, Pei-Pei Cheng, Lin-Jie Song, Li-Mei Liang, Xin-Liang He, Liang Xiong, Fei Xiang, Xiaorong Wang, Wan-Li Ma, Hong Ye
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Cell Communication and Signaling
Subjects:
PM2.5
Asthma
Remodeling
BMAL1
p53
Autophagy
Online Access:https://doi.org/10.1186/s12964-023-01057-9

Internet

https://doi.org/10.1186/s12964-023-01057-9

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