Intestinal Microbiota Reduction Followed by Fasting Discloses Microbial Triggering of Inflammation in Rheumatoid Arthritis

Rheumatoid arthritis (RA) synovitis is dominated by monocytes/macrophages with inflammatory patterns resembling microbial stimulation. In search of triggers, we reduced the intestinal microbiome in 20 RA patients (open label study DRKS00014097) by bowel cleansing and 7-day fasting (≤250 kcal/day) an...

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Main Authors: Thomas Häupl, Till Sörensen, Biljana Smiljanovic, Marine Darcy, Justus Scheder-Bieschin, Nico Steckhan, Anika M. Hartmann, Daniela A. Koppold, Bruno Stuhlmüller, Karl Skriner, Barbara M. Walewska, Berthold Hoppe, Marc Bonin, Gerd R. Burmester, Pascal Schendel, Eugen Feist, Karsten Liere, Martin Meixner, Christian Kessler, Andreas Grützkau, Andreas Michalsen
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Journal of Clinical Medicine
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Online Access:https://www.mdpi.com/2077-0383/12/13/4359