Combination of mangiferin and T0901317 targeting autophagy promotes cholesterol efflux from macrophage foam cell in atherosclerosis

Combination of mangiferin and T0901317 targeting autophagy promotes cholesterol efflux from macrophage foam cell in atherosclerosis

Abstract Background The synthetic liver X receptor ligand (LXR) T0901317 (T0) has been reported to attenuate atherosclerosis (AS) without hyperglyceridemia due to innovative drug combination or nano-sized drug delivery. Given the key roles of mangiferin (MGF) in lipid metabolism and atherogenesis, i...

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Bibliographic Details
Main Authors: Qian Chen, Sijian Wang, Ruixia Bao, Dan Wang, Yuzheng Wu, Yi Zhang, Mengyang Liu, Tao Wang
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Chinese Medicine
Subjects:
Mangiferin
T0901317
Cholesterol efflux
Autophagy
Macrophage foam cells
Online Access:https://doi.org/10.1186/s13020-023-00876-9

Internet

https://doi.org/10.1186/s13020-023-00876-9

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