IL-12 DNA Displays Efficient Adjuvant Effects Improving Immunogenicity of Ag85A in DNA Prime/MVA Boost Immunizations

IL-12 DNA Displays Efficient Adjuvant Effects Improving Immunogenicity of Ag85A in DNA Prime/MVA Boost Immunizations

Mycobacterium tuberculosis (Mtb) infection is one of the leading causes of death worldwide. The Modified Vaccinia Ankara (MVA) vaccine vector expressing the mycobacterial antigen 85A (MVA85A) was demonstrated to be safe, although it did not improve BCG efficacy, denoting the need to search for impro...

Full description

Bibliographic Details
Main Authors: María Paula Morelli, María Paula Del Medico Zajac, Joaquín Miguel Pellegrini, Nicolás Oscar Amiano, Nancy Liliana Tateosian, Gabriela Calamante, María Magdalena Gherardi, Verónica Edith García
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Ag85A
DNA vaccine
IL-12
MVA
tuberculosis
vaccine
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2020.581812/full

Internet

https://www.frontiersin.org/article/10.3389/fcimb.2020.581812/full

Similar Items