FOXO3 mutation predicting gefitinib-induced hepatotoxicity in NSCLC patients through regulation of autophagy

FOXO3 mutation predicting gefitinib-induced hepatotoxicity in NSCLC patients through regulation of autophagy

Hepatotoxicity is a common side effect for patients treated with gefitinib, but the related pathogenesis is unclear and lacks effective predictor and management strategies. A multi-omics approach integrating pharmacometabolomics, pharmacokinetics and pharmacogenomics was employed in non-small cell l...

Full description

Bibliographic Details
Main Authors: Shaoxing Guan, Xi Chen, Youhao Chen, Guohui Wan, Qibiao Su, Heng Liang, Yunpeng Yang, Wenfeng Fang, Yan Huang, Hongyun Zhao, Wei Zhuang, Shu Liu, Fei Wang, Wei Feng, Xiaoxu Zhang, Min Huang, Xueding Wang, Li Zhang
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Gefitinib
Hepatotoxicity
Pharmacometabolomic
Pharmacokinetics
Pharmacogenomics
FOXO3
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383522000557

Internet

http://www.sciencedirect.com/science/article/pii/S2211383522000557

Similar Items