Engineering Peptide Inhibitors of the HFE–Transferrin Receptor 1 Complex

Engineering Peptide Inhibitors of the HFE–Transferrin Receptor 1 Complex

The protein HFE (homeostatic iron regulator) is a key regulator of iron metabolism, and mutations in HFE underlie the most frequent form of hereditary haemochromatosis (HH-type I). Studies have shown that HFE interacts with transferrin receptor 1 (TFR1), a homodimeric type II transmembrane glycoprot...

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Bibliographic Details
Main Authors: Daniela Goncalves Monteiro, Gautam Rishi, Declan M. Gorman, Guillaume Burnet, Randy Aliyanto, K. Johan Rosengren, David M. Frazer, V. Nathan Subramaniam, Richard J. Clark
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Molecules
Subjects:
hepcidin
stapling
HFE
TFR1
Online Access:https://www.mdpi.com/1420-3049/27/19/6581

Internet

https://www.mdpi.com/1420-3049/27/19/6581

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