Characterization of aspartokinase double mutants using a combination of experiments and simulations
Aspartokinase (AK) is synergistically suppressed by Thr and Lys in the Corynebacterium metabolic pathway. Site-directed mutations can significantly improve AK inhibition. Our previous studies confirmed that sites 379 and 380 were important sites affecting enzyme activity, so we further screen the do...
Main Authors: | Zhijie Chen, Yu Fu, Shimeng Liu, Xinyu Huang, Xiaoting Kong, Zhaojie Mao, Ning Hu, Fengxiang Zhang, Caijing Han |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2023-02-01
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Series: | Heliyon |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023003407 |
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