Presenilin-1 F105C mutation leads to tau accumulation in human neurons via the Akt/mTORC1 signaling pathway

Presenilin-1 F105C mutation leads to tau accumulation in human neurons via the Akt/mTORC1 signaling pathway

Abstract Background The mammalian target of rapamycin (mTOR) plays a critical role in controlling cellular homeostasis, and its dysregulation has been implicated in Alzheimer’s disease (AD). Presenilin-1 (PS1) mutations account for the most common causes of familial Alzheimer’s disease (FAD); howeve...

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Bibliographic Details
Main Authors: Cheong-Meng Chong, Yuan Tan, Jiaqi Tong, Minjing Ke, Ke Zhang, Lingli Yan, Xiaotong Cen, Jia-Hong Lu, Guobing Chen, Huanxing Su, Dajiang Qin
Format: Article
Language:English
Published: BMC 2022-08-01
Series:Cell & Bioscience
Subjects:
mTOR
Presenilin-1
iPSC
CRISPR/Cas9
Online Access:https://doi.org/10.1186/s13578-022-00874-8

Internet

https://doi.org/10.1186/s13578-022-00874-8

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