Pregnancy-Associated Plasma Protein-A2 Is Associated With Mortality in Patients With Lung Cancer

Pregnancy-Associated Plasma Protein-A2 Is Associated With Mortality in Patients With Lung Cancer

Pregnancy-associated plasma protein-A (PAPP-A) and its homolog PAPP-A2 are enzymes that modulate the availability and mitogenic activity of insulin-like growth factor-I (IGF-I). PAPP-A has been implicated in numerous cancers but reports on PAPP-A2 in malignancy are non-existent. In a prospective obs...

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Bibliographic Details
Main Authors: Rikke Hjortebjerg, Ulrick Espelund, Torben Riis Rasmussen, Birgitte Folkersen, Torben Steiniche, Jeanette Bæhr Georgsen, Claus Oxvig, Jan Frystyk
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Endocrinology
Subjects:
insulin-like growth factor
insulin-like growth factor binding protein
lung cancer
mortality
pregnancy-associated plasma protein-A
pregnancy-associated plasma protein-A2
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2020.00614/full

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https://www.frontiersin.org/article/10.3389/fendo.2020.00614/full

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