Empirical Bayes functional models for hydrogen deuterium exchange mass spectrometry
A statistical analysis approach for HDX-MS time series data incorporates correlations in time, reducing false positives and improving statistical power and data interpretation.
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-06-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-022-03517-3 |
| _version_ | 1811344869586632704 |
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| author | Oliver M. Crook Chun-wa Chung Charlotte M. Deane |
| author_facet | Oliver M. Crook Chun-wa Chung Charlotte M. Deane |
| author_sort | Oliver M. Crook |
| collection | DOAJ |
| description | A statistical analysis approach for HDX-MS time series data incorporates correlations in time, reducing false positives and improving statistical power and data interpretation. |
| first_indexed | 2024-04-13T19:54:38Z |
| format | Article |
| id | doaj.art-755fa39cd4bc49a696ebdff9a168d7f9 |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-04-13T19:54:38Z |
| publishDate | 2022-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-755fa39cd4bc49a696ebdff9a168d7f92022-12-22T02:32:22ZengNature PortfolioCommunications Biology2399-36422022-06-015111010.1038/s42003-022-03517-3Empirical Bayes functional models for hydrogen deuterium exchange mass spectrometryOliver M. Crook0Chun-wa Chung1Charlotte M. Deane2Department of Statistics, University of OxfordStructural and Biophysical Sciences, GlaxoSmithKline R&DDepartment of Statistics, University of OxfordA statistical analysis approach for HDX-MS time series data incorporates correlations in time, reducing false positives and improving statistical power and data interpretation.https://doi.org/10.1038/s42003-022-03517-3 |
| spellingShingle | Oliver M. Crook Chun-wa Chung Charlotte M. Deane Empirical Bayes functional models for hydrogen deuterium exchange mass spectrometry Communications Biology |
| title | Empirical Bayes functional models for hydrogen deuterium exchange mass spectrometry |
| title_full | Empirical Bayes functional models for hydrogen deuterium exchange mass spectrometry |
| title_fullStr | Empirical Bayes functional models for hydrogen deuterium exchange mass spectrometry |
| title_full_unstemmed | Empirical Bayes functional models for hydrogen deuterium exchange mass spectrometry |
| title_short | Empirical Bayes functional models for hydrogen deuterium exchange mass spectrometry |
| title_sort | empirical bayes functional models for hydrogen deuterium exchange mass spectrometry |
| url | https://doi.org/10.1038/s42003-022-03517-3 |
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