Characterization of glucocorticoid-induced loss of DNA methylation of the stress-response gene Fkbp5 in neuronal cells

Characterization of glucocorticoid-induced loss of DNA methylation of the stress-response gene Fkbp5 in neuronal cells

Exposure to stress or glucocorticoids (GCs) is associated with epigenetic and transcriptional changes in genes that either mediate or are targets of GC signalling. FKBP5 (FK506 binding protein 5) is one such gene that also plays a central role in negative feedback regulation of GC signalling and sev...

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Bibliographic Details
Main Authors: Olivia H. Cox, Ha Young Song, Henri M. Garrison-Desany, Nuriya Gadiwalla, Jenny L. Carey, Julia Menzies, Richard S. Lee
Format: Article
Language:English
Published: Taylor & Francis Group 2021-12-01
Series:Epigenetics
Subjects:
hpa axis
dna methylation
glucocorticoids
fkbp5
cell replication
Online Access:http://dx.doi.org/10.1080/15592294.2020.1864169

Internet

http://dx.doi.org/10.1080/15592294.2020.1864169

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