Pharmacological HDAC inhibition impairs pancreatic β-cell function through an epigenome-wide reprogramming

Pharmacological HDAC inhibition impairs pancreatic β-cell function through an epigenome-wide reprogramming

Summary: Histone deacetylases enzymes (HDACs) are chromatin modifiers that regulate gene expression through deacetylation of lysine residues within specific histone and non-histone proteins. A cell-specific gene expression pattern defines the identity of insulin-producing pancreatic β cells, yet mol...

Full description

Bibliographic Details
Main Authors: Frédérik Oger, Maeva Moreno, Mehdi Derhourhi, Bryan Thiroux, Lionel Berberian, Cyril Bourouh, Emmanuelle Durand, Souhila Amanzougarene, Alaa Badreddine, Etienne Blanc, Olivier Molendi-Coste, Laurent Pineau, Gianni Pasquetti, Laure Rolland, Charlène Carney, Florine Bornaque, Emilie Courty, Céline Gheeraert, Jérôme Eeckhoute, David Dombrowicz, Julie Kerr-Conte, François Pattou, Bart Staels, Philippe Froguel, Amélie Bonnefond, Jean-Sébastien Annicotte
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:iScience
Subjects:
Natural sciences
Biological sciences
Molecular biology
Molecular mechanism of gene regulation
Epigenetics
Endocrinology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223013081

Internet

http://www.sciencedirect.com/science/article/pii/S2589004223013081

Similar Items