Hypersensitivity of BRCA2 deficient cells to rosemary extract explained by weak PARP inhibitory activity

Hypersensitivity of BRCA2 deficient cells to rosemary extract explained by weak PARP inhibitory activity

Abstract Rosemary extract is used in food additives and traditional medicine and has been observed to contain anti-tumor activity. In this study, rosemary extract is hypothesized to induce synthetic lethality in BRCA2 deficient cells by PARP inhibition. Chinese hamster lung V79 cells and its mutant...

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Bibliographic Details
Main Authors: Cathy Su, Jeffrey P. Gius, Julia Van Steenberg, Alexis H. Haskins, Kazuki Heishima, Chisato Omata, Masahiro Iwayama, Mami Murakami, Takashi Mori, Kohji Maruo, Takamitsu A. Kato
Format: Article
Language:English
Published: Nature Portfolio 2017-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-16795-3

Internet

https://doi.org/10.1038/s41598-017-16795-3

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