Palmitoylation regulates the magnitude of HCN4-mediated currents in mammalian cells

Palmitoylation regulates the magnitude of HCN4-mediated currents in mammalian cells

The sinoatrial node (SAN) and subsidiary pacemakers in the cardiac conduction system generate spontaneous electrical activity which is indispensable for electrical and therefore contractile function of the heart. The hyperpolarisation-activated cyclic nucleotide-gated channel HCN4 is responsible for...

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Bibliographic Details
Main Authors: Samitha Dilini Congreve, Alice Main, Andrew S. Butler, Xing Gao, Elaine Brown, Chunyun Du, Stephanié C. Choisy, Hongwei Cheng, Jules C. Hancox, William Fuller
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Physiology
Subjects:
sinoatrial node
funny current
acylation
heart rate
ion channel
palmitoylation
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2023.1163339/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2023.1163339/full

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