The m7G Methyltransferase Mettl1 Drives Cardiac Hypertrophy by Regulating SRSF9‐Mediated Splicing of NFATc4

The m7G Methyltransferase Mettl1 Drives Cardiac Hypertrophy by Regulating SRSF9‐Mediated Splicing of NFATc4

Abstract Cardiac hypertrophy is a key factor driving heart failure (HF), yet its pathogenesis remains incompletely elucidated. Mettl1‐catalyzed RNA N7‐methylguanosine (m7G) modification has been implicated in ischemic cardiac injury and fibrosis. This study aims to elucidate the role of Mettl1 and t...

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Bibliographic Details
Main Authors: Shuting Yu, ZhiYong Sun, Tiantian Ju, Yingqi Liu, Zhongting Mei, Changhao Wang, Zhezhe Qu, Na Li, Fan Wu, KuiWu Liu, Meixi Lu, Min Huang, Xiaochen Pang, Yingqiong Jia, Ying Li, Yaozhi Zhang, Shunkang Dou, Jianhao Jiang, Xianhui Dong, Chuanhao Huang, Wanhong Li, Yi zhang, Ye Yuan, Baofeng Yang, Weijie Du
Format: Article
Language:English
Published: Wiley 2024-08-01
Series:Advanced Science
Subjects:
alternative splicing
cardiac hypertrophy
m7G
Mettl1
NFATc4
Online Access:https://doi.org/10.1002/advs.202308769

Internet

https://doi.org/10.1002/advs.202308769

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