Secreted Frizzled Related Protein 5 (SFRP5) Serum Levels Are Decreased in Critical Illness and Sepsis and Are Associated with Short-Term Mortality

Secreted Frizzled Related Protein 5 (SFRP5) Serum Levels Are Decreased in Critical Illness and Sepsis and Are Associated with Short-Term Mortality

Sepsis is a major health burden with insufficiently understood mechanisms of inflammation and immune paralysis, leading to a life-threatening critical illness. The secreted frizzled related protein 5 (SFRP5) acts as an anti-inflammatory adipokine by antagonizing the Wnt5a pathway. The aim of this st...

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Bibliographic Details
Main Authors: Philipp Hohlstein, Jonathan F. Brozat, Julia Schuler, Samira Abu Jhaisha, Maike R. Pollmanns, Lukas Bündgens, Theresa H. Wirtz, Eray Yagmur, Karim Hamesch, Ralf Weiskirchen, Frank Tacke, Christian Trautwein, Alexander Koch
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Biomedicines
Subjects:
intensive care unit
critical illness
sepsis
human
cytokine
adipokine
Online Access:https://www.mdpi.com/2227-9059/11/2/313

Internet

https://www.mdpi.com/2227-9059/11/2/313

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