T cell migration requires ion and water influx to regulate actin polymerization

T cell migration requires ion and water influx to regulate actin polymerization

Abstract Migration of T cells is essential for their ability to mount immune responses. Chemokine-induced T cell migration requires WNK1, a kinase that regulates ion influx into the cell. However, it is not known why ion entry is necessary for T cell movement. Here we show that signaling from the ch...

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Bibliographic Details
Main Authors: Leonard L. de Boer, Lesley Vanes, Serena Melgrati, Joshua Biggs O’May, Darryl Hayward, Paul C. Driscoll, Jason Day, Alexander Griffiths, Renata Magueta, Alexander Morrell, James I. MacRae, Robert Köchl, Victor L. J. Tybulewicz
Format: Article
Language:English
Published: Nature Portfolio 2023-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-43423-8

Internet

https://doi.org/10.1038/s41467-023-43423-8

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