Aging‐Associated ALKBH5‐m6A Modification Exacerbates Doxorubicin‐Induced Cardiomyocyte Apoptosis Via AT‐Rich Interaction Domain 2

Aging‐Associated ALKBH5‐m6A Modification Exacerbates Doxorubicin‐Induced Cardiomyocyte Apoptosis Via AT‐Rich Interaction Domain 2

Background Chemotherapy‐induced cardiovascular disease is a growing concern in the elderly population who have survived cancer, yet the underlying mechanism remains poorly understood. We investigated the role of ALKBH5 (AlkB homolog 5), a primary N6‐methyladenosine (m6A) demethylase, and its involve...

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Bibliographic Details
Main Authors: Runtai Chen, Guogang Zhang, Kun Sun, Alex F. Chen
Format: Article
Language:English
Published: Wiley 2024-01-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
aging
ALKBH5
cardiotoxicity
doxorubicin
m6A
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.123.031353

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.123.031353

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