Gp96 Peptide Antagonist gp96-II Confers Therapeutic Effects in Murine Intestinal Inflammation

Gp96 Peptide Antagonist gp96-II Confers Therapeutic Effects in Murine Intestinal Inflammation

BackgroundThe expression of heat shock protein gp96 is strongly correlated with the degree of tissue inflammation in ulcerative colitis and Crohn’s disease, thereby leading us to the hypothesis that inhibition of expression via gp96-II peptide prevents intestinal inflammation.MethodsWe employed dail...

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Bibliographic Details
Main Authors: Claudia A. Nold-Petry, Marcel F. Nold, Ofer Levy, Yossef Kliger, Anat Oren, Itamar Borukhov, Christoph Becker, Stefan Wirtz, Manjeet K. Sandhu, Markus Neurath, Charles A. Dinarello
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Immunology
Subjects:
Gp96
cytokines and inflammation
biologics
therapeutics
immunemodulatory
anti-inflammatory agent
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01531/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01531/full

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