T cell self-reactivity during thymic development dictates the timing of positive selection

T cell self-reactivity during thymic development dictates the timing of positive selection

Functional tuning of T cells based on their degree of self-reactivity is established during positive selection in the thymus, although how positive selection differs for thymocytes with relatively low versus high self-reactivity is unclear. In addition, preselection thymocytes are highly sensitive t...

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Bibliographic Details
Main Authors: Lydia K Lutes, Zoë Steier, Laura L McIntyre, Shraddha Pandey, James Kaminski, Ashley R Hoover, Silvia Ariotti, Aaron Streets, Nir Yosef, Ellen A Robey
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-04-01
Series:eLife
Subjects:
thymocyte
positive selection
self-reactivity
TCR
ion channels
Online Access:https://elifesciences.org/articles/65435

Internet

https://elifesciences.org/articles/65435

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