Shiga toxin type-2 (Stx2) induces glutamate release via phosphoinositide 3-kinase (PI3K) pathway in murine neurons.

Shiga toxin type-2 (Stx2) induces glutamate release via phosphoinositide 3-kinase (PI3K) pathway in murine neurons.

Shiga toxin-producing Escherichia coli (STEC) can cause central nervous system (CNS) damage resulting in paralysis, seizures, and coma. The key STEC virulence factors associated with systemic illness resulting in CNS impairment are Shiga toxins (Stx). While neurons express the Stx receptor globotri...

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Bibliographic Details
Main Authors: Fumiko eObata, Lauren M Hippler, Progyaparamita eSaha, Dakshina M Jandhyala, Olga eLatinovic
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-07-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Escherichia coli
Glutamates
Neurons
Shiga Toxin 2
super resolution microscopy
PI3K pathway
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnmol.2015.00030/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnmol.2015.00030/full

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