Mild phenotype of knockouts of the major apurinic/apyrimidinic endonuclease APEX1 in a non-cancer human cell line.

Mild phenotype of knockouts of the major apurinic/apyrimidinic endonuclease APEX1 in a non-cancer human cell line.

The major human apurinic/apyrimidinic (AP) site endonuclease, APEX1, is a central player in the base excision DNA repair (BER) pathway and has a role in the regulation of DNA binding by transcription factors. In vertebrates, APEX1 knockouts are embryonic lethal, and only a handful of knockout cell l...

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Bibliographic Details
Main Authors: Daria V Kim, Liliya M Kulishova, Natalia A Torgasheva, Vasily S Melentyev, Grigory L Dianov, Sergey P Medvedev, Suren M Zakian, Dmitry O Zharkov
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0257473

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https://doi.org/10.1371/journal.pone.0257473

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