Effects of N-glycan modifications on spike expression, virus infectivity, and neutralization sensitivity in ancestral compared to Omicron SARS-CoV-2 variants.

Effects of N-glycan modifications on spike expression, virus infectivity, and neutralization sensitivity in ancestral compared to Omicron SARS-CoV-2 variants.

The SARS-CoV-2 spike glycoprotein has 22 potential N-linked glycosylation sites per monomer that are highly conserved among diverse variants, but how individual glycans affect virus entry and neutralization of Omicron variants has not been extensively characterized. Here we compared the effects of s...

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Bibliographic Details
Main Authors: Sabrina Lusvarghi, Charles B Stauft, Russell Vassell, Brittany Williams, Haseebullah Baha, Wei Wang, Sabari Nath Neerukonda, Tony Wang, Carol D Weiss
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-11-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1011788

Internet

https://doi.org/10.1371/journal.ppat.1011788

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