N-glycosylation acts as a switch for FGFR1 trafficking between the plasma membrane and nuclear envelope

N-glycosylation acts as a switch for FGFR1 trafficking between the plasma membrane and nuclear envelope

Abstract Fibroblast growth factor receptor 1 (FGFR1) is a heavily N-glycosylated cell surface receptor tyrosine kinase that transmits signals across the plasma membrane, in response to fibroblast growth factors (FGFs). Balanced FGF/FGFR1 signaling is crucial for the development and homeostasis of th...

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Bibliographic Details
Main Authors: Paulina Gregorczyk, Natalia Porębska, Dominika Żukowska, Aleksandra Chorążewska, Aleksandra Gędaj, Agata Malinowska, Jacek Otlewski, Małgorzata Zakrzewska, Łukasz Opaliński
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Cell Communication and Signaling
Subjects:
Glycosylation
FGFR1
Trafficking
Nucleus
Signaling
Online Access:https://doi.org/10.1186/s12964-023-01203-3

Internet

https://doi.org/10.1186/s12964-023-01203-3

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